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MELISA DIRCHWOLF

MELISA DIRCHWOLFMD

Hepatóloga & Subjefe de Trasplante Hepático, Hospital Privado de Rosario y Sanatorio Británico

Hospital Privado de RosarioRosarioORCID 0000-0002-9083-3561
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About

Melisa Dirchwolf es médica hepatóloga y Subjefe de Trasplante Hepático en el Hospital Privado de Rosario, Argentina, donde forma parte del Staff de la Unidad de Hígado y Trasplante Hepático desde 2017. Es especialista certificada en Hepatología por la Asociación Argentina para el Estudio de las Enfermedades del Hígado (SAHE) y cuenta con formación internacional en trasplante hepático en la Universidad de Colorado y en el Inselspital de Berna, Suiza. Con más de 51 publicaciones indexadas en PubMed y un H-index de 21, ha contribuido activamente a guías de práctica clínica latinoamericanas y argentinas en MASLD, hepatocarcinoma y hepatitis virales, y desempeña una destacada labor docente en múltiples programas de posgrado de hepatología.

Areas of focus

Hepatología y Trasplante HepáticoTrasplante hepáticoHepatología clínicaEnfermedad hepática grasa metabólica (MASLD)HepatocarcinomaHepatitis virales (B y C)Cirrosis e hipertensión portalInvestigación clínica en enfermedades hepáticasFormación de especialistas en hepatología

Experience & education

Subjefe de Trasplante Hepático · Hospital Privado de Rosario

Rosario, Santa Fe, Argentina

2024 — Present

Co-directora del Workshop for Young Investigators – ALEH and AASLD · Congreso Latinoamericano de Hepatología ALEH

Ciudad de México

2026 — 2026

Subcomisión de Docencia e Investigación · Sociedad Argentina de Hepatología (SAHE)

2025 — Present

Docente – Materia Taller de Tesis, Maestría de Investigación Clínica · Instituto Universitario del Hospital Italiano de Buenos Aires

2024 — Present

Staff – Unidad de Hígado y Trasplante Hepático · Hospital Privado de Rosario

Rosario, Santa Fe, Argentina

2017 — Present

Vocal – Comisión Directiva · Sociedad Argentina de Hepatología (SAHE)

2021 — 2025

Maestría de Efectividad Clínica I.E.C.S · Universidad de Buenos Aires

Buenos Aires, Argentina

2021 — 2022

Investigadora – Ministerio de Salud de la Nación · Ministerio de Salud de la Nación Argentina

Registro RENIS IN005180

2020 — Present

Investigadora · Fundación Diagnóstico Cardiovascular de Rosario

Rosario, Argentina

2020 — 2020

Hepatology Fellow – SwissLiver Foundation · Inselspital

Berna, Suiza (Beca Novartis)

2019 — 2019

Especialista en Hepatología · Asociación Argentina para el Estudio de las Enfermedades del Hígado (SAHE)

Buenos Aires, Argentina

2015 — 2015

Scholar in Research and Training in Transplant Hepatology · University of Colorado, Denver School of Medicine

Transplant Hepatology Unit, Colorado, United States

2014 — 2014

Concurrente en Hepatología · Hospital Francisco J. Muñiz

Unidad de Hepatopatías Infecciosas, Buenos Aires, Argentina

2011 — 2014

Becaria en Trasplante Hepático · Fundación para la Docencia e Investigación de las Enfermedades del Hígado (FUNDIEH) – Hospital Británico

Buenos Aires, Argentina

2011 — 2011

Especialista en Clínica Médica – Residencia Nacional · Hospital Julio C. Perrando

Resistencia, Chaco, Argentina

2008 — 2011

Médica · Universidad Nacional del Nordeste (U.N.N.E)

Facultad de Medicina, Argentina

2002 — 2008

Publications

Prospective surveillance reveals high rates of antimicrobial resistance in urinary tract infections among patients with cirrhosis.

Vazquez, Carolina, Gomez Perdiguero, Gonzalo, Ballerga, Esteban Gonzalez, Pardo Ivirico, Ilse, Briz, Camila M, Di Santo, Agustin, et al. · Annals of hepatology · 2026PubMed

Updated recommendations for the management of metabolic dysfunction-associated steatotic liver disease (MASLD) by the Latin American working group.

Diaz, Luis Antonio, Arab, Juan Pablo, Idalsoaga, Francisco, Perelli, Javiera, Vega, Javier, Dirchwolf, Melisa, et al. · Annals of hepatology · 2025PubMed

Increasing Treatment Uptake for Chronic Hepatitis B in South America: A Comparative Analysis of Country-Specific and WHO 2024 Guidelines.

Mendizabal, Manuel, Sabate, Constanza D, Gonzalez Ballerga, Esteban, Gruz, Fernando, Ridruejo, Ezequiel, Soza, Alejandro, et al. · Journal of viral hepatitis · 2025PubMed

Towards evidence-based empiric antibiotic recommendations for spontaneous infections in patients with cirrhosis.

Dirchwolf, Melisa, Gomez Perdiguero, Gonzalo, Cairo, Fernando, Vazquez, Carolina, Notari, Lorena, Murga, Maria Dolores, et al. · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2025PubMed

Development and external validation of a model to predict multidrug-resistant bacterial infections in patients with cirrhosis.

Marciano, Sebastian, Piano, Salvatore, Singh, Virendra, Caraceni, Paolo, Maiwall, Rakhi, Alessandria, Carlo, et al. · Liver international : official journal of the International Association for the Study of the Liver · 2024PubMed

An artificial intelligence-generated model predicts 90-day survival in alcohol-associated hepatitis: A global cohort study.

Dunn, Winston, Li, Yanming, Singal, Ashwani K, Simonetto, Douglas A, Diaz, Luis A, Idalsoaga, Francisco, et al. · Hepatology (Baltimore, Md.) · 2024PubMed

Editorial: Terlipressin and MDRO colonisation in cirrhosis-Is there a causal link?

Revelli, Luciano, Dirchwolf, Melisa · Alimentary pharmacology & therapeutics · 2024PubMed

Procedural-Related Bleeding in Hospitalized Patients With Liver Disease (PROC-BLeeD): An International, Prospective, Multicenter Observational Study.

Intagliata, Nicolas M, Rahimi, Robert S, Higuera-de-la-Tijera, Fatima, Simonetto, Douglas A, Farias, Alberto Queiroz, Mazo, Daniel F, et al. · Gastroenterology · 2023PubMed

MELD 3.0 adequately predicts mortality and renal replacement therapy requirements in patients with alcohol-associated hepatitis.

Diaz, Luis Antonio, Fuentes-Lopez, Eduardo, Ayares, Gustavo, Idalsoaga, Francisco, Arnold, Jorge, Valverde, Maria Ayala, et al. · JHEP reports : innovation in hepatology · 2023PubMed

Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay.

Vazquez, Carolina, Gutierrez-Acevedo, Maria Nelly, Barbero, Sabrina, Notari, Lorena Del Carmen, Agozino, Marina, Fernandez, Jose Luis, et al. · Annals of hepatology · 2023PubMed

Norfloxacin prophylaxis effect on multidrug resistance in patients with cirrhosis and bacterial infections.

Marciano, Sebastian, Gutierrez-Acevedo, Maria N, Barbero, Sabrina, Del C Notari, Lorena, Agozino, Marina, Fernandez, Jose L, et al. · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023PubMed

The impact of perceived donor liver quality on post-transplant outcome.

Dirchwolf, Melisa, Becchetti, Chiara, Stampf, Susanne, Haldimann, Christa, Immer, Franz, Beyeler, Franziska, et al. · ANZ journal of surgery · 2023PubMed

Challenges and recommendations when selecting empirical antibiotics in patients with cirrhosis.

Dirchwolf, Melisa, Gomez Perdiguero, Gonzalo, Grech, Ingrid Mc, Marciano, Sebastian · World journal of hepatology · 2023PubMed

Letter: PCSK9 inhibitor for liver transplant patients during the post-statin era? Authors' reply.

Becchetti, Chiara, Dirchwolf, Melisa, Berzigotti, Annalisa, Bosch, Jaume · Alimentary pharmacology & therapeutics · 2023PubMed

Letter: what explains improved survival from statin exposure after liver transplantation? Authors' reply.

Becchetti, Chiara, Dirchwolf, Melisa, Schropp, Jonas, Berzigotti, Annalisa, Bosch, Jaime · Alimentary pharmacology & therapeutics · 2022PubMed

Use of statins after liver transplantation is associated with improved survival: results of a nationwide study.

Becchetti, Chiara, Dirchwolf, Melisa, Schropp, Jonas, Magini, Giulia, Mullhaupt, Beat, Immer, Franz, et al. · Alimentary pharmacology & therapeutics · 2022PubMed

The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality.

Dirchwolf, Melisa, Becchetti, Chiara, Gschwend, Sarah G, Toso, Christian, Dutkowski, Philipp, Immer, Franz, et al. · HPB : the official journal of the International Hepato Pancreato Biliary Association · 2022PubMed

The establishment of public health policies and the burden of non-alcoholic fatty liver disease in the Americas.

Diaz, Luis Antonio, Fuentes-Lopez, Eduardo, Ayares, Gustavo, Idalsoaga, Francisco, Arnold, Jorge, Marquez-Lomas, Andrea, et al. · The lancet. Gastroenterology & hepatology · 2022PubMed

From Child-Pugh to MELD score and beyond: Taking a walk down memory lane.

Ruf, Andres, Dirchwolf, Melisa, Freeman, Richard B · Annals of hepatology · 2022PubMed

Identification of optimal therapeutic window for steroid use in severe alcohol-associated hepatitis: A worldwide study.

Arab, Juan Pablo, Diaz, Luis Antonio, Baeza, Natalia, Idalsoaga, Francisco, Fuentes-Lopez, Eduardo, Arnold, Jorge, et al. · Journal of hepatology · 2021PubMed

Failure in all steps of hepatocellular carcinoma surveillance process is frequent in daily practice.

Dirchwolf, Melisa, Marciano, Sebastian, Ruf, Andres E, Singal, Amit G, D'Ercole, Vanina, Coisson, Paola, et al. · Annals of hepatology · 2021PubMed

NAFLD: Challenges and opportunities to address the public health problem in Latin America.

Arab, Juan Pablo, Diaz, Luis Antonio, Dirchwolf, Melisa, Mark, Henry E, Lazarus, Jeffrey V, Vaughan, Elly, et al. · Annals of hepatology · 2021PubMed

The Latin American Association for the Study of the Liver (ALEH) position statement on the redefinition of fatty liver disease.

Mendez-Sanchez, Nahum, Arrese, Marco, Gadano, Adrian, Oliveira, Claudia P, Fassio, Eduardo, Arab, Juan Pablo, et al. · The lancet. Gastroenterology & hepatology · 2021PubMed

Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease.

Arab, Juan Pablo, Dirchwolf, Melisa, Alvares-da-Silva, Mario Reis, Barrera, Francisco, Benitez, Carlos, Castellanos-Fernandez, Marlene, et al. · Annals of hepatology · 2020PubMed

Outbreak of hepatitis A in a post-vaccination era: High rate of co-infection with sexually transmitted diseases.

Marciano, Sebastian, Arufe, Diego, Haddad, Leila, Mendizabal, Manuel, Gadano, Adrian, Gaite, Luis, et al. · Annals of hepatology · 2020PubMed

The Importance of Knowing the Local Epidemiology When a Patient With Cirrhosis Acquires a Bacterial Infection.

Marciano, Sebastian, Valverde, Marcelo, Dirchwolf, Melisa, Gutierrez-Acevedo, Maria Nelly, Gadano, Adrian · Clinical liver disease · 2020PubMed

Argentinian clinical practice guideline for surveillance, diagnosis, staging and treatment of hepatocellular carcinoma.

Pinero, Federico, Tanno, Mario, Aballay Soteras, Gabriel, Tisi Bana, Matias, Dirchwolf, Melisa, Fassio, Eduardo, et al. · Annals of hepatology · 2020PubMed

Biomarkers in Hepatocellular Carcinoma: Diagnosis, Prognosis and Treatment Response Assessment.

Pinero, Federico, Dirchwolf, Melisa, Pessoa, Mario G · Cells · 2020PubMed

Impact of acute-on-chronic liver failure on post-transplant survival and on kidney outcomes.

Marciano, Sebastian, Mauro, Ezequiel, Giunta, Diego, Torres, Maria C, Diaz, Juan M, Bermudez, Carla, et al. · European journal of gastroenterology & hepatology · 2019PubMed

Spontaneous bacterial peritonitis recurrence in patients with cirrhosis receiving secondary prophylaxis with norfloxacin.

Marciano, Sebastian, Dirchwolf, Melisa, Diaz, Juan M, Bermudez, Carla, Gutierrez-Acevedo, Maria N, Barcan, Laura A, et al. · European journal of gastroenterology & hepatology · 2019PubMed

Spontaneous bacterial peritonitis in patients with cirrhosis: incidence, outcomes, and treatment strategies.

Marciano, Sebastian, Diaz, Juan Manuel, Dirchwolf, Melisa, Gadano, Adrian · Hepatic medicine : evidence and research · 2019PubMed

Unresolved issues in the prophylaxis of bacterial infections in patients with cirrhosis.

Dirchwolf, Melisa, Marciano, Sebastian, Martinez, Jose, Ruf, Andres Eduardo · World journal of hepatology · 2018PubMed

Review article: drug-induced liver injury in the context of nonalcoholic fatty liver disease - a physiopathological and clinical integrated view.

Bessone, Fernando, Dirchwolf, Melisa, Rodil, Maria Agustina, Razori, Maria Valeria, Roma, Marcelo G · Alimentary pharmacology & therapeutics · 2018PubMed

Trends in liver transplantation for hepatitis C in a country with reduced access to direct-acting antiviral agents.

Dirchwolf, Melisa, Marciano, Sebastian, Giunta, Diego H, Posadas-Martinez, Maria L, Biggins, Scott W, Ruf, Andres E · Clinical transplantation · 2018PubMed

Spontaneous bacteremia and spontaneous bacterial peritonitis share similar prognosis in patients with cirrhosis: a cohort study.

Marciano, Sebastian, Dirchwolf, Melisa, Bermudez, Carla S, Sobenko, Natalia, Haddad, Leila, Genre Bert, Federico, et al. · Hepatology international · 2018PubMed

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