Prof. ⁨Guan-Huei Lee⁩MBBS, MRCP, FRCP, PhD

Senior Consultant & Head, Division of Gastroenterology and Hepatology, National University Hospital

National University HospitalSingaporeORCID 0000-0002-8652-6403

Talks given

Publications

Followers

Years

About

Dr. Guan-Huei Lee is a Senior Consultant and Head of the Division of Gastroenterology and Hepatology at National University Hospital, Singapore, and an Adjunct Associate Professor at the National University of Singapore. He holds a PhD from NUS and fellowship of the Royal College of Physicians of Edinburgh, with an h-index of 28 and over 4,000 citations. His clinical and research interests encompass viral hepatitis, hepatocellular carcinoma, liver failure, and liver transplantation, and he has contributed to major international guidelines in these areas.

Areas of focus

Gastroenterology & HepatologyViral hepatitis (HBV, HCV, HEV)Hepatocellular carcinomaAcute-on-chronic liver failureLiver transplantationHepatic encephalopathyMetabolic dysfunction-associated fatty liver diseaseDrug resistance in hepatitis BEndoscopic and interventional hepatology

Experience & education

Head, Division of Gastroenterology and Hepatology · National University Hospital

Singapore

2021 — Present

Gastroenterology Cluster Lead · National University Health System

Singapore

2021 — Present

Group Lead, Thematic Sub-group (Education, Research, and Innovation) · National Liver Transplant Programme

Singapore

2022 — Present

Clinical Functional Planning Unit Lead, NUH Redevelopment Project · National University Hospital

Singapore

2025 — Present

Singapore Medical Council Complaints Panel Member · Singapore Medical Council

2025 — Present

Director, Clinical Services · National University Centre for Organ Transplantation

Singapore

2019 — 2022

Medical Director, Liver Transplantation · National University Centre for Organ Transplantation

Singapore

2018 — 2021

Research Director, Gastroenterology and Hepatology · National University Hospital

Singapore

2012 — Present

Senior Consultant · National University Hospital

Division of Gastroenterology & Hepatology, Department of Medicine

Present

Adjunct Associate Professor · National University of Singapore

Department of Medicine

Present

PhD · National University of Singapore

2014

FRCP Edinburgh · Royal College of Physicians of Edinburgh

2015

MRCP · Royal College of Physicians (UK)

2004

MBBS · National University of Singapore

1999

Publications

Characterisation of liver disease using quantitative MRI: report of the imaging arm of the ELEGANCE study.

Wang, Yi-Chun, Wong, Yu Jun, Jackson, Edward, Dennis, Andrea, Riddell, Sophie, Chong, Oi Fong, et al. · BMC gastroenterology · 2026PubMed

Precision medicine for G-CSF in ACLF: the biomarker gap.

Lee, Guan-Huei · Hepatology international · 2026PubMed

Exploration and discovery of treatment targets for primary biliary cholangitis based on plasma and cerebrospinal fluid proteomics: A multicenter mendelian randomization study.

Xi, Jianxin, Wang, Shengnan, Chen, Jie, Law, Jason Chi Shing, Wang, Jianglong, Lee, Guan Huei, et al. · PloS one · 2026PubMed

Rising burden of metabolic dysfunction-associated steatotic liver disease in adolescents aged 15-19 years and projections to 2035.

Wang, Youxin, Oza, Noriko, Chirapongsathorn, Sakkarin, Lee, Shi Yan, Tan, Eunice X X, Lee, Guan Huei, et al. · Diabetes research and clinical practice · 2025PubMed

Impact of Diabetes, Drug-Induced Liver Injury, and Sepsis on Outcomes in Metabolic Dysfunction Associated Fatty Liver Disease-Related Acute-on-Chronic Liver Failure.

Kumar, Ashish, Arora, Anil, Choudhury, Ashok, Arora, Vinod, Rela, Mohamed, Jothimani, Dinesh Kumar, et al. · The American journal of gastroenterology · 2025PubMed

Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Choudhury, Ashok, Kulkarni, Anand V, Arora, Vinod, Soin, A S, Dokmeci, Abdul Kadir, Chowdhury, Abhijeet, et al. · Hepatology international · 2025PubMed

Knowledge and awareness of perinatal antiviral use in the prevention of mother-to-child hepatitis B virus transmission among maternal chronic hepatitis carriers.

Low, Jia Ming, Ma, Ting, Lee, Guan-Huei, Lee, Le Ye · Singapore medical journal · 2024PubMed

Endoscopic Bariatric and Metabolic Therapies and Their Effects on Metabolic Syndrome and Non-alcoholic Fatty Liver Disease - A Systematic Review and Meta-Analysis.

Lee, Shi-Yan, Lai, Haoxing, Chua, Yang Jie, Wang, Min Xian, Lee, Guan-Huei · Frontiers in medicine · 2022PubMed

Parapharyngeal metastasis in hepatocellular carcinoma-a rare entity.

Chee, J, Lee, G H, Ooi, L Y, Seet, J E, Loh, T, Ng, L S · International journal of oral and maxillofacial surgery · 2021PubMed

Impact of COVID-19 on Liver Transplantation in Hong Kong and Singapore: A Modelling Study.

Tan, Eunice Xiang-Xuan, Quek, Wei Liang, Suryadi, Chahed, Haroun, Iyer, Shridhar Ganpathi, Jeyaraj, Prema Raj, et al. · The Lancet regional health. Western Pacific · 2021PubMed

Poor Outcomes of Cirrhosis due to Nonalcoholic Steatohepatitis Compared With Hepatitis B After Decompensation With Ascites.

Tan, Hiang Keat, Teng, Margaret Li Peng, Soh, Alex Yu Sen, Cheo, Sara Hui Yi, Fook-Chong, Stephanie, Goh, George Boon Bee, et al. · The American journal of gastroenterology · 2021PubMed

CpG-Adjuvanted Hepatitis B Vaccine (HEPLISAV-B(R)) Update.

Lee, Guan-Huei, Lim, Seng-Gee · Expert review of vaccines · 2021PubMed

Predicting HCC Response to Multikinase Inhibitors With In Vivo Cirrhotic Mouse Model for Personalized Therapy.

Huang, Daniel Q, Muthiah, Mark D, Zhou, Lei, Jumat, Halisah, Tan, Wan Xin, Lee, Guan Huei, et al. · Cellular and molecular gastroenterology and hepatology · 2021PubMed

Cost-effectiveness analysis of antiviral treatment for pregnant women with high viral load to prevent hepatitis B virus vertical transmission.

Ma, Ting, Lee, Le Ye, Aw, Marion M, Lee, Guan Huei · Singapore medical journal · 2020PubMed

Maternal HBeAg positivity and viremia associated with umbilical cord blood hepatitis B viremia.

Lee, Le Ye, Lee, Guan Huei, Mattar, Citra, Saw, Sharon, Aw, Marion · Pediatrics and neonatology · 2019PubMed

Asian Liver Transplant Network Clinical Guidelines on Immunosuppression in Liver Transplantation.

Tan, Poh Seng, Muthiah, Mark D, Koh, Tsingyi, Teoh, Yee Leong, Chan, Albert, Kow, Alfred, et al. · Transplantation · 2019PubMed

Patterns of mutation within an emerging endemic lineage of HEV-3a.

Zhu, Yuan O, Aw, Pauline, Aung, Myo Myint, Lee, Hong Kai, Hibberd, Martin, Lee, Guan Huei · Journal of viral hepatitis · 2019PubMed

Comparison of cobas HCV GT against Versant HCV Genotype 2.0 (LiPA) with confirmation by Sanger sequencing.

Yusrina, Falah, Chua, Cui Wen, Lee, Chun Kiat, Chiu, Lily, Png, Tracy Si-Yu, Khoo, Mui Joo, et al. · Journal of virological methods · 2018PubMed

Limited benefit of hepatitis B immunoglobulin prophylaxis in children of hepatitis B e antigen-negative mothers.

Lee, Le Ye, Aw, Marion M, Saw, Sharon, Rauff, Mary, Tong, Pearl Ys, Lee, Guan Huei · Singapore medical journal · 2016PubMed

Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk.

Lee, Guan-Huei, Tan, Boon-Huan, Teo, Esmeralda Chi-Yuan, Lim, Seng-Gee, Dan, Yock-Young, Wee, Aileen, et al. · Gastroenterology · 2016PubMed

Hepatitis B immunoprophylaxis failure and the presence of hepatitis B surface gene mutants in the affected children.

Lee, Le Ye, Aw, Marion, Rauff, Mary, Loh, Kah-Sin, Lim, Seng Gee, Lee, Guan Huei · Journal of medical virology · 2015PubMed

Search for a cure for chronic hepatitis B infection: How close are we?

Phyo, Wah Wah, Soh, Alex Yu Sen, Lim, Seng Gee, Lee, Guan Huei · World journal of hepatology · 2015PubMed

Editorial: IDASPHERE phase I trial for chemoembolisation of HCC.

Lee, G H, Lim, S G · Alimentary pharmacology & therapeutics · 2014PubMed

Hepatitis B pregenomic RNA splicing--the products, the regulatory mechanisms and its biological significance.

Lee, Guan Huei, Wasser, Shanthi, Lim, Seng Gee · Virus research · 2008PubMed

Connect

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