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Prof. ⁨Ashraf Osman⁩

Prof. ⁨Ashraf Osman⁩MD, FAASLD

Professor of Hepatology & Liver Transplant Consultant | President, Egyptian Society of Liver Cancer | MENA NCCN Hepatobiliary Cancer Committee Chairman

Cairo UniversityCairo EgyptORCID 0000-0002-5370-5421
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Years

About

Dr. Ashraf Omar Abdel Aziz Osman is a Professor of Hepatology and Tropical Medicine at the Faculty of Medicine, Cairo University, and a Liver Transplant Consultant at Cairo University Hospitals and Dar Al-Fouad Hospital, with more than four decades of clinical and academic experience. He is the Founder and Director of the Multidisciplinary HCC Clinic at Cairo University and serves as President of the Egyptian Society of Liver Cancer (ESLC), Chairman of the MENA NCCN Hepatobiliary Cancer Committee, and Co-Founder of the Africa Hepato-Pancreato-Biliary Cancer Consortium. His work spans hepatocellular carcinoma care, liver transplantation, international guideline development, and capacity building across Egypt, the Middle East and North Africa, and sub-Saharan Africa.

Areas of focus

HepatologyHepatocellular carcinoma (HCC) diagnosis and managementMultidisciplinary liver cancer careLiver transplantation and living-donor liver transplantationLocoregional therapy (TACE, microwave and radiofrequency ablation)Systemic therapy for advanced HCCViral hepatitis (HCV/HBV) and related liver diseaseHCC biomarkers and translational researchInternational guideline and consensus development

Experience & education

Founder & Director, Multidisciplinary HCC Clinic · Cairo University

2009 — Present

Professor of Hepatology & Tropical Medicine · Cairo University

Faculty of Medicine

2007 — Present

Consultant Hepatologist, Liver Clinic · National Cancer Institute (NCI)

Cairo, Egypt

2005 — Present

Liver Transplant Consultant · Cairo University Hospitals & Dar Al-Fouad Hospital

Cairo, Egypt

2001 — Present

Visiting Professor · MD Anderson Cancer Center

Houston, Texas, USA

2010 — 2010

Visiting Professor · University of New Mexico (UNM)

USA

2008 — 2008

Visiting Professor · University of Wisconsin–Milwaukee

USA

2007 — 2007

Associate Professor of Hepatology & Tropical Medicine · Cairo University

Faculty of Medicine

2002 — 2007

Visiting Professor · Dumont-UCLA Transplant Center / Pfleger Liver Institute, David Geffen School of Medicine at UCLA

USA

2005 — 2005

Visiting Professor, Liver Transplantation Center · University of Essen

Essen, Germany

2002 — 2002

Lecturer of Hepatology & Tropical Medicine · Cairo University

Faculty of Medicine

1997 — 2002

MD, Tropical Medicine · Cairo University

Faculty of Medicine

1996 — 1996

Assistant Lecturer of Hepatology & Tropical Medicine · Cairo University

Faculty of Medicine

1986 — 1996

MSc, Tropical Medicine · Cairo University

Faculty of Medicine

1986 — 1986

Resident, Hepatology & Tropical Medicine Department · Cairo University

1983 — 1986

House Officer · Kasr Al-Aini Hospitals, Cairo University

1982 — 1983

MB BCh · Cairo University

1981 — 1981

Publications

Mapping HLA class I and II allele associations with hepatitis C related liver disease progression in an Egyptian cohort.

M Lotfy, Mai, Ebrahim, Noura A A, El-Kassas, Mohamed, Omar Abdel-Aziz, Ashraf, Abdelhamid Omran, Dalia, Abdelfatah, Dalia, et al. · Discover oncology · 2026PubMed

Establishing cancer registries in Africa - focus on hepatopancreatobiliary cancers.

Asombang, Akwi W, Antwi, Samuel O, Omonisi, Abidemi, Cooley, Matthew A, Nartey, Yvonne A, VanLith, Caitlin J, et al. · Nature reviews. Gastroenterology & hepatology · 2026PubMed

Assessment of GALAD score as a diagnostic and prognostic factor of de novo hepatitis C-related hepatocellular carcinoma post treatment with direct-acting antivirals.

Ramadan, Ahmed, Abdelaziz, Ashraf Omar, Nabeel, Mohamed Mahmoud, Atef, Mirna, Kamel, Mai Hamed, Elbaz, Tamer Mahmoud, et al. · Hepatology forum · 2026PubMed

SOX9 and TNFAIP3 dysregulation in HCV-associated HCC after DAA therapy: insights into post-viral oncogenic memory.

Moustafa, Rehab I, Farouk, Sally, Elsayed, Hassan, Shousha, Hend I, Elbrashy, Maha M, Gabr, Ahmed M, et al. · Infectious agents and cancer · 2026PubMed

Outcomes and Survival of Egyptian Patients With Hepatitis B-Related Hepatocellular Carcinoma: A Multicentre Retrospective Study.

Barakat, Eman M F, Kohla, Mohamed, Tawheed, Ahmed, Shousha, Hend Ibrahim, Moustafa, Ehab F, Said, Mohamed, et al. · Journal of viral hepatitis · 2026PubMed

Two-Decade Trends in MASLD and Its Complications in the Middle East and North Africa (2010-2021).

Younossi, Zobair M, Paik, James M, Yilmaz, Yusuf, Kanat, Mustafa, El-Kassas, Mohamed, Al-Busafi, Said A, et al. · Liver international : official journal of the International Association for the Study of the Liver · 2025PubMed

Assessment of peripheral gene expression signatures as predictive biomarkers for hepatocellular carcinoma following DAA treatment.

Moustafa, Rehab I, Farouk, Sally, Bader El Din, Noha G, Shousha, Hend I, Khairy, Ahmed, Elesnawy, Yasser K, et al. · Journal, genetic engineering & biotechnology · 2025PubMed

Tyrosine kinase inhibitors were well-tolerated among patients with different etiologies of advanced HCC with lower survival in non-viral patients.

Barakat, Eman M F, Kohla, Mohamed, Dabees, Hossam, Shousha, Hend Ibrahim, Moustafa, Ehab F, El-Kassas, Mohamed, et al. · Scientific reports · 2025PubMed

Survival of patients with non-viral hepatocellular carcinoma treated with trans-arterial chemoembolization: A multicenter cohort study.

Shousha, Hend Ibrahim, Barakat, Eman M F, Rewisha, Eman, El-Kassas, Mohamed, Moustafa, Ehab Fawzy, Said, Mohamed, et al. · Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology · 2025PubMed

Characteristics and survival of patients with viral versus nonviral associated hepatocellular carcinoma: a multicenter cohort study.

El-Kassas, Mohamed, Barakat, Eman M F, Shousha, Hend Ibrahim, Kohla, Mohamed, Said, Mohamed, Moustafa, Ehab Fawzy, et al. · European journal of gastroenterology & hepatology · 2025PubMed

Complete Genomic Landscape Reveals Hidden Evolutionary History and Selection Signature in Asian Water Buffaloes (Bubalus bubalis).

Si, Jingfang, Dai, Dongmei, Gorkhali, Neena Amatya, Wang, Mingshan, Wang, Sheng, Sapkota, Saroj, et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024PubMed

OncomiR-181a promotes carcinogenesis by repressing the extracellular matrix proteoglycan decorin in hepatocellular carcinoma.

Assal, Reem Amr, Abd El-Bary, Rowan Bahaa El-Din, Youness, Rana A, Abdelrahman, Mohamed Mamdouh, Zahran, Hala, Hosny, Karim Adel, et al. · BMC gastroenterology · 2024PubMed

Multidisciplinary consensus recommendations for management of hepatocellular carcinoma in Middle East and North Africa region.

Waked, Imam, Alsammany, Sherif, Tirmazy, Sayed Hammad, Rasul, Kakil, Bani-Issa, Jafar, Abdel-Razek, Wael, et al. · Liver international : official journal of the International Association for the Study of the Liver · 2023PubMed

Egyptian Society of Liver Cancer Recommendation Guidelines for the Management of Hepatocellular Carcinoma.

Omar, Ashraf, Kaseb, Ahmed, Elbaz, Tamer, El-Kassas, Mohamed, El Fouly, Amr, Hanno, Abdel Fatah, et al. · Journal of hepatocellular carcinoma · 2023PubMed

Africa Guidelines for Hepatocellular Carcinoma Buildup Process.

Abou-Alfa, Ghassan K, Afihene, Mary, Capanu, Marinela, Li, Yuelin, Chou, Joanne F, Asombang, Akwi, et al. · JCO global oncology · 2023PubMed

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