Evaluation of Cholestasis and PFIC: An Itch You Can’t Scratch

Cholestatic liver diseases present significant diagnostic and therapeutic challenges, particularly when patients experience persistent pruritus and unexplained abnormalities in liver biochemistry. Progressive Familial Intrahepatic Cholestasis (PFIC) represents a group of rare, genetically mediated disorders of bile formation and transport that can manifest across the lifespan.

This expert-led session will explore a practical approach to evaluating cholestasis, including the interpretation of liver biochemical tests, differential diagnosis, imaging, and the role of genetic testing in identifying inherited cholestatic disorders.

Special emphasis will be placed on the pathophysiology and clinical consequences of cholestatic pruritus, contemporary treatment strategies, and emerging therapies targeting bile acid transport and signaling pathways.

Participants will gain practical insights into recognizing PFIC, navigating diagnostic uncertainty, and developing individualized management strategies for patients with challenging cholestatic liver disease.